The Impact of Deep Brain Stimulation of the Subthalamic Nucleus on Sleep-Wake Function and Circadian Rhythms in Patients with Parkinson's Disease.

ABSTRACT:

Background

Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a well-established therapy in advanced Parkinson's disease (PD) improving motor and non-motor signs including sleep. The mechanisms of sleep improvement are insufficiently understood.

Objectives

The objective was to identify stimulation-dependent effects on the sleep-wake cycle and circadian clock regulation.

Methods

Fourteen PD patients who underwent STN DBS (PD-DBS) were assessed before as well as 6 and 12 months post-surgery. As control groups, 18 PD patients under best medical treatment (PD-CON) and 25 healthy controls (H-CON) were also enrolled. Wrist actigraphy to measure sleep and sleep questionnaires, such as the PD Sleep Scale (PDSS), were applied and the expression of clock genes in

SUBMITTER: Steinhardt J 

PROVIDER: S-EPMC12625183 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature