Genomic insights into Bordetella pertussis evolution and macrolide resistance in Yiwu, China.

ABSTRACT: Pertussis, caused by Bordetella pertussis, remains a significant public health concern despite widespread vaccination. Recent increases in macrolide-resistant strains present additional challenges for treatment and control. Yiwu, China-a highly mobile and international city-offers a unique setting to study the genomic evolution and antimicrobial resistance of B. pertussis. In this study, 63 clinical isolates from Yiwu underwent whole-genome sequencing. Over 90% of isolates showed high resistance to macrolides. Genome sizes ranged from 3.53 to 4.15 Mb, with high GC content (67.69-67.80%) and variable repeat rates. Phylogenetic analysis, incorporating 14 international strains, revealed two distinct clades and lineage-specific variations in key vaccine antigen genes, indicating multiple origi

SUBMITTER: Xu W 

PROVIDER: S-EPMC12625215 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature