Genomic characterization of XDR Mycobacterium tuberculosis isolates in Argentina (2006-2015).

ABSTRACT:

Background

Tuberculosis (TB), caused by the intracellular bacterium Mycobacterium tuberculosis complex (Mtbc), remains a significant global health challenge, with Mtbc once again being the leading infectious killer worldwide. Despite over a century of research, the disease continues to pose a major threat, with an estimated one-fourth of the global population latently infected. According to the World Health Organization (WHO), approximately 1.3 million deaths were attributed to TB in 2024 alone. The emergence of multidrug-resistant (MDR) strains, resistant to isoniazid and rifampicin, and extensively drug-resistant (XDR) strains, resistant to rifampicin (and may also be resistant to isoniazid), to at least one fluoroquinolone (levofloxacin or moxifloxacin) and to at least one other

SUBMITTER: Castello FA 

PROVIDER: S-EPMC12625239 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature