Prognostic significance of cytogenetic and molecular features in pediatric acute myeloid leukemia: a meta-analysis.

ABSTRACT:

Background

Pediatric acute myeloid leukemia (AML) is a clinically and genetically heterogeneous malignancy with variable outcomes. Accurate risk stratification based on cytogenetic and molecular markers is essential for guiding therapy. However, the prognostic impact of several key genomic alterations remains inconsistent across studies. This meta-analysis aims to evaluate the prognostic significance of cytogenetic and molecular abnormalities in pediatric AML and clarify their association with survival outcomes.

Methods

A systematic search was conducted across PubMed, EMBASE, Scopus, Web of Science, and CENTRAL up to May 5, 2025. Studies were included if they reported survival outcomes in pediatric patients (≤ 18 years) with de novo AML and evaluated cytogenetic or molecular

SUBMITTER: Huang Q 

PROVIDER: S-EPMC12625333 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature