Sodium-myoinositol cotransporter-1 downstream of m6A methyltransferase WTAP exerts a potential carcinogenicity in diffuse large B-cell lymphoma progression.

ABSTRACT:

Background

Diffuse large B-cell lymphoma (DLBCL) is the most common subtype of aggressive non-Hodgkin lymphoma, contributing significantly to global health and economic challenges. Sodium-myoinositol cotransporter-1 (SMIT1) acts as an oncogene in different types of cancer. This study aimed to explore [1] the role of SMIT1 in DLBCL development, and [2] whether N6-Methyladenosine (m6A) modifications were responsible for high SMIT1 expression within DLBCL tissues.

Methods

Expression of SMIT1 was modulated by a eukaryotic SMIT1-expressing plasmid or a plasmid specific to SMIT1-targeting shRNA. The impacts of SMIT1 overexpression or knockdown on DLBCL cell proliferation, cell cycle, and apoptosis were evaluated using cell-counting-kit-8, flow cytometry and western blot assays. A

SUBMITTER: Li X 

PROVIDER: S-EPMC12625369 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature