Renal transcriptome-wide analyses in association with kidney black carbon load.

ABSTRACT:

Rationale and objective

Inhaled black carbon (BC) has been previously shown to reach and accumulate in the kidneys. As kidneys filter toxicants, they may be susceptible to adverse effects caused by BC accumulation. We studied gene expressions and pathways related to BC particle load in kidney biopsy tissue.

Study design

Gene expression was measured in 29 kidney biopsies performed at one or two years post-transplantation using Affymetrix microarray. We performed a transcriptome-wide association analysis using linear regression analyses, adjusting for individual characteristics to investigate alterations in gene expression in association with kidney BC. Finally, we performed overrepresentation analyses (ConsensusPathDB) to identify enriched pathways and gene ontology sets.

SUBMITTER: Rasking L 

PROVIDER: S-EPMC12625452 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature