Transcriptomic insights into the anti-apoptotic effect of Tuina in rabbit model of intervertebral disc degeneration.

ABSTRACT:

Background

Tuina therapy is a promising treatment for spinal diseases, but its therapeutic mechanism remains poorly understood. Nucleus pulposus (NP) cell apoptosis is an important pathologic mechanism of intervertebral disc degeneration (IDD). We evaluated the intervention effect of sham-controlled placebo therapy on NP apoptosis in rabbit model of IDD and dissected the molecular mechanism by transcriptome analysis.

Methods

IDD rabbit model was established by using intervertebral disc fibrous annulus puncture, and the intervention was carried out for 4 weeks in the Tuina group and the Placebo group. The intervention effects of the two therapies were assessed by H&E staining, MRI scanning, Tunel staining and flow cytometry. Transcriptome analysis was performed to detect key

SUBMITTER: Ye J 

PROVIDER: S-EPMC12625494 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature