Dose-response association between circulating selenium and blood pressure: a systematic review and meta-analysis.

ABSTRACT:

Aim and scope

Hypertension is considered a global health issue due to its growing prevalence. Although several studies investigated the relationship between circulating selenium and hypertension, their results are inconsistent. Therefore, we aimed to examine this association through a systematic review and dose-response analysis.

Method

The research protocol has been registered with PROSPERO (CRD42024555841). A systematic search was performed across Medline/PubMed, Scopus, Clarivate Web of Science, and Google Scholar until December 2023. The analysis calculated summary relative risks (RR) and 95% confidence intervals (95% CI) for the risk of hypertension by comparing the highest versus lowest levels of circulating selenium and using random-effects models. Additionally, dose-

SUBMITTER: Khodadadi H 

PROVIDER: S-EPMC12625506 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature