Association of cumulative changes in atherogenic index of plasma and its obesity-related derivatives with cardiovascular disease: emphasis on incremental risk of diabetes status.

ABSTRACT:

Background

The atherogenic index of plasma (AIP) and obesity indices have been introduced as cost-effective indicators for cardiovascular disease (CVD) risk. We aimed to investigate the association between cumulative changes in AIP and its obesity-related derivatives (AIP, AIP-BMI, AIP-WC, AIP-WHtR, AIP-BRI, and AIP-CVAI) and CVD using a nationally representative cohort.

Methods

A total of 4,519 CVD-free participants from the China Health and Retirement Longitudinal Study were included. Based on repeated measurement data from Waves 1 and 3, we classified the control levels of AIP and its obesity-related derivatives using k-means clustering and evaluated their cumulative exposure. A multi-model joint analysis strategy was adopted to systematically assess the associations of c

SUBMITTER: Zhang N 

PROVIDER: S-EPMC12625564 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature