The mediation effect of sleep quality on the association between ambient air pollution and type 2 diabetes among UK adults: a population-based cohort study.

ABSTRACT:

Background

New evidence suggests that air pollution is associated with type 2 diabetes (T2D), but the underlying mechanisms are unclear. Therefore, we aimed to investigate the relationship between air pollution exposure and T2D and to quantify the role of sleep quality in this association.

Methods

A total of 226,188 participants free of T2D at baseline were enrolled in this prospective cohort study. Annual average concentrations of particulate matter (PM_2.5 and PM₁₀) and nitrogen oxides (NO₂, NO_X) were assessed using a land-use regression. Stratified Cox regression models and Aalen additive hazards models were used to estimate the association between air pollutants and T2D. Causal mediation modelling was used to estimate the indire

SUBMITTER: Lin Y 

PROVIDER: S-EPMC12625595 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature