Genomic insights into novel ST7947 carbapenem-resistant hypervirulent Klebsiella pneumoniae: a threat from an Indian hospital setting.

ABSTRACT:

Background

The rise of carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-hvKp) strains represents a major clinical threat, particularly in Asia. These strains possess both extensive drug resistance and enhanced virulence traits, leading to high morbidity and mortality. This study aimed to characterize the genomic profile of a CR-hvKp isolate (BB-7) obtained from a clinical case in eastern India and to investigate its resistance and virulence mechanisms.

Methods

K. pneumoniae BB-7 was obtained from the urine sample of a 75-year-old male and identified by using the VITEK2 system and ITS-PCR amplification. Hypervirulence was confirmed through the string test and detection of the iucA gene. The antimicrobial susceptibility (AST) was determined by the Kirby-Bauer disk

SUBMITTER: Behera B 

PROVIDER: S-EPMC12625628 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature