Unexplored diversity and molecular genetic signatures of chimallin and phuz encoding phages.

ABSTRACT: Nucleus-forming phages are a class of jumbo phages with the capacity to form a protein nuclear shell during infection within a bacterial host. This protein nuclear shell protects the replication of the phage genome by excluding host defense factors. However, the lack of genetic characterization of these phages limits our understanding of nucleus-forming phages. Here, we used HMMER and RoseTTAFold to identify a proposed dataset of nucleus-forming phages, based on the presence of chimallin and PhuZ tubulin genes, containing the 1103 phage genomes (including 406 high quality genomes) from 16 million published phage genomes. These high quality phages genomes range in length were from 200 to 324 kb. A cluster analysis conducted using vConTACT2 revealed that these phages could be classified into

SUBMITTER: Sun S 

PROVIDER: S-EPMC12625630 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature