Association between early prophylactic heparin therapy and mortality in patients with septic shock secondary to respiratory infections: analysis based on MIMIC-IV database.

ABSTRACT:

Background

Septic shock is a life-threatening syndrome often triggered by respiratory infections, frequently accompanied by coagulation dysfunction, leading to high mortality rates. Heparin, as an anticoagulant, exhibits multiple effects, but its specific prognostic value in such patients remains unclear.

Objective

To investigate association between early prophylactic heparin therapy and mortality in patients with septic shock secondary to respiratory infections.

Methods

Patient data were extracted from MIMIC-IV database. Inverse probability of treatment weighting (IPTW) was used to adjust for confounding variables. Kaplan-Meier (K-M) curves were utilized to assess survival rates. Cox proportional hazards model was employed to evaluate relationship between early proph

SUBMITTER: Chen X 

PROVIDER: S-EPMC12625647 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature