Agreement of treatment effects in decentralised trials versus traditional trials: meta-epidemiological study.

ABSTRACT:

Objective

To compare treatment effects from trials designed as decentralised trials or as traditional non-decentralised trials.

Design

Meta-epidemiological study.

Data source

PubMed database.

Eligibility criteria

Trials identified as decentralised and included in meta-analyses alongside corresponding non-decentralised trials, restricted to drug interventions across all populations and outcome types.

Results

51 decentralised trials and 86 non-decentralised trials regarding 11 clinical questions were compared. Decentralised trials were larger than non-decentralised trials (median sample size 1175 v 236 participants) and more recent than non-decentralised trials (median year of publication 2012 v 2007). The level of significance agreed between

SUBMITTER: Chaboud L 

PROVIDER: S-EPMC12625687 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature