Gut-larynx axis and its contribution to laryngeal immunity.

ABSTRACT: The larynx is vital for swallowing, breathing, coughing, and voice production, supported by its unique microbial and immunological environment. We hypothesized the existence of a gut-larynx axis, where resident gut and laryngeal microbiota influence immune modulation in the larynx. To test this, conventionally raised, wild-type C57BL/6 J mice were treated with an oral antibiotic regimen to disrupt gut microbiota and compared with untreated controls. Antibiotic treatment significantly disrupted gut microbiota but left laryngeal microbiota largely unaffected. However, antibiotic-treated mice showed notable changes in laryngeal epithelial and immune cells, as well as fibroblasts. Differential gene expression analysis revealed alterations in pathways related to epithelial barrier integrity, im

SUBMITTER: An R 

PROVIDER: S-EPMC12625719 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature