Pre-CT risk stratification using the D-dimer/pCO₂ ratio in D-dimer-positive emergency department patients: diagnostic accuracy study.

ABSTRACT:

Background

The diagnostic utility of the D-dimer/pCO₂ ratio for pulmonary embolism (PE) risk stratification has not been fully established. This study evaluated its diagnostic performance among emergency department patients with positive age-adjusted D-dimer results undergoing computed tomography pulmonary angiography (CTPA).

Methods

This retrospective diagnostic accuracy study included 698 adult patients with positive age-adjusted D-dimer results, venous blood gas (VBG) pCO₂ measurements, and definitive CTPA interpretation. The D-dimer/pCO₂ ratio was calculated, and receiver operating characteristic (ROC) analysis was performed. Optimal and exploratory thresholds were assessed for overall PE detection and for excluding central PE. Robustness was tested using bootstrap valid

SUBMITTER: Yıldırım C 

PROVIDER: S-EPMC12625727 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature