Porcine deltacoronavirus infection promotes intracellular lipid droplet accumulation.

ABSTRACT:

Background

Viruses critically depend on host lipid metabolism to drive replication, assembly and immune evasion during infection and pathogenesis. While previous studies have demonstrated that certain viruses induce lipid droplet accumulation in infected host cells, lipid droplets have been reported to exert either proviral or antiviral effects across different research contexts. The present study investigates how porcine deltacoronavirus (PDCoV) regulates lipid droplet biogenesis and fatty acid synthesis in LLC-PK1 cells, with the aim of elucidating the potential molecular mechanisms and regulatory gene targets that govern lipid droplet homeostasis during infection.

Methods

First, we characterized PDCoV's impact on lipid droplet homeostasis in LLC-PK1 cells using immunofluo

SUBMITTER: Yang X 

PROVIDER: S-EPMC12625732 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature