Multi-omics analysis reveals the mechanism of <i>Lactobacillus plantarum</i> in alleviating metabolic disorders in type 2 diabetic mice through the gut-liver axis.

ABSTRACT: Type 2 diabetes mellitus (T2DM) mainly induced by high-fat diets (HFD) is becoming a prevalent and serious metabolic disease worldwide. Although probiotics are considered a treatment for T2DM, the underlying mechanisms and therapeutic effects of the specific strain remain unclear. Thus, elucidating the strain-dependent mechanisms and identifying effective probiotic strains for T2DM management are critically needed. In this study, Lactobacillus plantarum was administered to HFD-induced T2DM mice to evaluate its effects on fasting blood glucose (FBG), body weight (BW), gut microbiota (GM) composition, gut metabolites, and liver gene expression. We found that L. plantarum supplementation significantly reduced FBG, insulin levels, and BW, while ameliorating liver and pancreatic d

SUBMITTER: Zhang C 

PROVIDER: S-EPMC12625740 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature