Multiomics analysis reveals signatures of selection and loci associated with complex traits in pigs.

ABSTRACT: The genetic basis of complex traits and phenotypic differentiation remains unclear in pigs. Using nine genomes-seven of which were newly generated, high-quality de novo assembled genomes-and 1081 resequencing genomes, we built a pan-genome and identified 134.24 Mb nonredundant nonreference sequences, 1099 novel protein-coding genes, 187,927 structural variations (SVs) and 30,143,962 single-nucleotide polymorphisms (SNPs). Analysis of selective domestication revealed BRCA1 associated with enhanced adipocyte growth and fat deposition, and ABCA3 linked to an alleviated immune response and reduced lung injury. Integrating 162 transcriptomes and 162 methylomes of skeletal muscle across 27 developmental stages revealed the regulatory mechanism of phenotypic differentiation between

SUBMITTER: Liu L 

PROVIDER: S-EPMC12625778 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature