Comparable 5-Year Survival in People With and Without HIV Following Hepatocellular Carcinoma Diagnosis: A Multicenter Study.

ABSTRACT:

Background and aims

Conflicting data on hepatocellular carcinoma (HCC) survival in people with HIV (PWH) may depend on tumour aggressiveness and access to curative treatments. We compared outcomes of two HCC cohorts according to HIV status.

Methods

Patients from four tertiary referral centers in Northern Italy with the first HCC diagnosis (2005-2023) were analysed. Clinical characteristics, treatment access, and overall survival (OS) were described by HIV status, using inverse probability treatment weighting and propensity score (IPTW/PS) methods. Cox regression models assessed mortality predictors and recurrence after initial treatment.

Results

Among 606 patients, 143 were PWH and 463 HIV-negative. PWH were younger (median age 53 vs. 68 years, p < 0.001), predominant

SUBMITTER: Iavarone M 

PROVIDER: S-EPMC12625804 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature