Stimuli-responsive STING nanovaccine for systemic therapy of HPV-induced cancers.

ABSTRACT: In recent years, therapeutic cancer vaccines have been extensively investigated, aiming to boost cancer-specific T cells crucial for antitumor activity. The effectiveness of these vaccines is often limited by insufficient immune activation and suboptimal antigen delivery. Stimulator of interferon genes (STING) is an important immune signaling protein that activates host defense genes against infection and cancer. Clinical evaluation of small-molecule STING agonists has shown tepid antitumor responses with immune-related toxicities, particularly when they are administered systemically. To overcome these limitations, we report a stimuli-responsive STING nanovaccine for treating human papillomavirus (HPV)-induced cancers. The nanovaccine consists of di-amidobenzimidazoles (diABZI) conjugated

SUBMITTER: Chen S 

PROVIDER: S-EPMC12625860 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature