Phenotypically driven subgroups of primary antiphospholipid syndrome-associated thrombocytopenia display distinct outcomes: a prospective cohort study with cluster analysis.

ABSTRACT:

Objectives

To identify antiphospholipid antibody-associated thrombocytopenia (aPLs-TP) phenotypes and assess their clinical outcomes.

Methods

This single-centre, prospective cohort study (January 2012 to April 2024) consecutively enrolled patients with aPLs-TP from Peking Union Medical College Hospital. Inclusion required persistent aPL positivity (≥12 weeks apart) and platelet (PLT) count <100×10⁹/L twice, excluding secondary causes. Demographic aPL profiles and clinical outcomes (thrombosis, pregnancy morbidity, microangiopathy and valve disease) were analysed. Hierarchical clustering and Kaplan-Meier survival analysis were performed.

Results

A total of 123 patients (65.9% female, mean age 36.0 years) were consecutively enrolled in the study. Median PLT c

SUBMITTER: Li J 

PROVIDER: S-EPMC12625884 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature