Dorsal horn-enriched genes identified by DNA microarray, in situ hybridization and immunohistochemistry.

ABSTRACT:

Background

Neurons in the dorsal spinal cord play important roles in nociception and pain. These neurons receive input from peripheral sensory neurons and then transmit the signals to the brain, as well as receive and integrate descending control signals from the brain. Many molecules important for pain transmission have been demonstrated to be localized to the dorsal horn of the spinal cord. Further understanding of the molecular interactions and signaling pathways in the dorsal horn neurons will require a better knowledge of the molecular neuroanatomy in the dorsal spinal cord.

Results

A large scale screening was conducted for genes with enriched expression in the dorsal spinal cord using DNA microarray and quantitative real-time PCR. In addition to genes known to be speci

SUBMITTER: Sun H 

PROVIDER: S-EPMC126259 | biostudies-literature | 2002 Aug

REPOSITORIES: biostudies-literature