Frailty and the risk of ICU-acquired infections in a randomised trial: a protocol and statistical analysis plan.

ABSTRACT:

Introduction

Dysregulated immunity may account for an increased risk of infection and other adverse outcomes among frail hospitalised persons. The primary objective of this study is to examine whether baseline frailty is associated with the risk of developing ventilator-associated pneumonia (VAP) or other intensive care unit (ICU)-acquired infections among invasively ventilated adults. Additional objectives are to examine the relationship between frailty and hospital length of stay, discharge to a long-term care facility and vital status. We hypothesise that persons with frailty compared with others would have an increased risk of VAP and other infections, a longer hospital stay, higher probability of discharge to a long-term care facility and higher mortality.

Methods and analy

SUBMITTER: Fernando SM 

PROVIDER: S-EPMC12625914 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature