Reprogramming tumor microenvironment via systemic delivery of TLR3 agonist and manganese nanoparticle.

ABSTRACT: Toll-like receptor (TLR) agonists, as potent immunostimulatory adjuvants, play a critical role in linking the innate and adaptive immune responses. However, their antitumor effects as cancer immunotherapeutic agents have been limited. Here, we report our finding that manganese ion (Mn²⁺) potentiates various TLR agonists, leading to robust activation of the TLR pathway and the stimulator of interferon genes (STING) pathway among innate immune cells. In particular, we have observed robust antitumor efficacy after intratumoral administration of a TLR3 agonist and Mn²⁺. To achieve systemic codelivery of TLR3 agonist and Mn²⁺, we have developed a low-molecular-weight poly(inosinic:cytidylic acid)-Mn²⁺ coordination lipid nanoparticle (PLCMP). When admi

SUBMITTER: Cho YS 

PROVIDER: S-EPMC12626007 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature