Recombinant newcastle disease virus expressing a foreign viral antigen is attenuated and highly immunogenic in primates.

ABSTRACT: Paramyxoviruses such as human parainfluenza viruses that bear inserts encoding protective antigens of heterologous viruses can induce an effective immunity against the heterologous viruses in experimental animals. However, vectors based on common human pathogens would be expected to be restricted in replication in the adult human population due to high seroprevalence, an effect that would reduce vector immunogenicity. To address this issue, we evaluated Newcastle disease virus (NDV), an avian paramyxovirus that is serotypically distinct from common human pathogens, as a vaccine vector. Two strains were evaluated: the attenuated vaccine strain LaSota (NDV-LS) that replicates mostly in the chicken respiratory tract and the Beaudette C (NDV-BC) strain of intermediate virulence that produces m

SUBMITTER: Bukreyev A 

PROVIDER: S-EPMC1262603 | biostudies-literature | 2005 Nov

REPOSITORIES: biostudies-literature