Novelty preference assessed by eye tracking: A sensitive measure of impaired recognition memory in epilepsy.

ABSTRACT:

Objective

Epilepsy patients often report memory deficits despite normal objective testing, suggesting that available measures are insensitive or that non-mnemonic factors are involved. The Visual Paired Comparison Task (VPCT) assesses novelty preference, the tendency to fixate on novel images rather than previously viewed items, requiring recognition memory for the "old" images. As novelty preference is a sensitive measure of hippocampal-dependent memory function, we predicted impaired VPCT performance in epilepsy patients compared to healthy controls.

Methods

We assessed 26 healthy adult controls and 31 epilepsy patients (16 focal-onset, 13 generalized-onset, 2 unknown-onset) with the VPCT using delays of 2 or 30 s between encoding and recognition. Fifteen healthy controls

SUBMITTER: Leeman-Markowski BA 

PROVIDER: S-EPMC12626093 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature