Feeding the Skin Barrier: The Impact of Macro- and Micronutrients on Skin Barrier Function.

ABSTRACT:

Background

Skin is the largest organ of the human body, and acts as a fundamental barrier. Beyond its protective role, it serves as a key immune organ, mediating immune surveillance and regulation. Exposure to environmental factors such as mechanical trauma, detergents, air pollution, and microbial dysbiosis can compromise the skin barrier triggering the release of pro-inflammatory cytokines that contribute to the pathogenesis of allergic diseases including atopic dermatitis (AD). Nutrition profoundly impacts skin health, influencing cell proliferation, tissue repair, and immune functions.

Methods

This review aims to explore the relationship between diet and skin barrier function, with a specific focus on AD.

Results

The evidence on micro- and macronutrients, probioti

SUBMITTER: Ryczaj K 

PROVIDER: S-EPMC12626168 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature