¹⁵N NMR Signal Amplification by Reversible Exchange of [¹⁵N₃]Ornidazole Antibiotic.

ABSTRACT: Hyperpolarization techniques provide a dramatic enhancement of the sensitivity of magnetic resonance spectroscopy and imaging. Signal amplification by reversible exchange in shield enables alignment transfer to heteronuclei (SABRE-SHEATH) is an efficient technique for hyperpolarization of ¹³C and ¹⁵N nuclei in various biologically relevant compounds. Nitroimidazole antibiotics are prone to reduction under anaerobic conditions, making them prospective molecular contrast agents for the visualization of hypoxic tumors. In this work, we systematically studied ¹⁵N SABRE-SHEATH hyperpolarization of the ornidazole antibiotic at natural abundance (n.a.) of the ¹⁵N isotope and in the isotopically ¹⁵N₃-labeled form. Optimization of su

SUBMITTER: Yi AP 

PROVIDER: S-EPMC12626227 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature