Preparing for the Inevitable: Early Comprehensive Genomic Profiling for Patients With Localized Pancreatic Ductal Adenocarcinoma.

ABSTRACT:

Purpose

Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease, even for patients diagnosed at a radiographically localized stage. Despite disease recurrence in most patients who undergo curative-intent therapy, national guidelines do not currently recommend comprehensive genomic profiling (CGP) until progression occurs following treatment. As the number of approved and investigational therapies expands for PDAC, ensuring access to early CGP data is critical for implementing molecularly informed treatment strategies.

Methods

We performed a single-institution, retrospective analysis of CGP utilization and treatment patterns in patients with localized PDAC who underwent curative-intent resection in the contemporary period during which CGP was recommended for all pa

SUBMITTER: Agritelley ES 

PROVIDER: S-EPMC12626397 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature