The Renal Activity Index for Lupus: Validation for Prediction of Kidney Inflammation in Adult Patients with Lupus Nephritis.

ABSTRACT:

Objective

To evaluate the ability of the Renal Activity Index for Lupus (RAIL) score, a urine biomarker-derived score, to capture and predict the course of active LN in adult patients.

Methods

Available serial urine samples collected up to week 52 from a subset of adults with active biopsy-proven proliferative LN participating in the double-blind randomized ALLURE trial of abatacept (NCT01714817) were used to calculate RAIL-scores from creatinine-adjusted urine biomarkers (NGAL, KIM-1, MCP-1, adiponectin, hemopexin, ceruloplasmin). Discriminative performance of RAIL-scores alone over time were compared with urine protein-to-creatinine-ratio (UPCR), kidney function (eGFR), and mixed model analysis of RAIL-score adjusted for baseline UPCR, eGFR, age, weight, sex, and race (RAI

SUBMITTER: O'Connor SK 

PROVIDER: S-EPMC12626405 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature