Effects of High- Versus Low-Sodium Oxybate on Blood Pressure in Patients With Narcolepsy.

ABSTRACT:

Background

People with narcolepsy are at increased risk for hypertension and cardiovascular disease; excessive sodium intake is linked to both.

Methods

We studied patients with narcolepsy and office systolic blood pressures (BPs) of 130 to 155 mm Hg taking twice-nightly high-sodium oxybate for ≥6 weeks who switched to low-sodium oxybate at the same dosage. The primary end point was the change from baseline in mean 24-hour ambulatory systolic BP at the end of treatment (≈6 weeks after switching). Secondary and exploratory end points included changes in diastolic BP, office BP, and 24-hour sodium excretion.

Results

Patients (n=43) had a mean age of 45 years, were 65% female, 33% on antihypertensives, with baseline mean (SD) office BP of 138.0/85.2 (5.7/6.6). Mean (SD) t

SUBMITTER: White WB 

PROVIDER: S-EPMC12626475 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature