Renal TRPM3 Channels Regulate Blood Pressure via Tubuloglomerular Feedback and Plasma Volume Control.

ABSTRACT:

Background

TRPM3 is a nonselective cation channel activated by heat, osmotic pressure, and neurosteroids. It is highly expressed in sensory neurons, where it integrates thermal, chemical, and inflammatory signals to modulate downstream responses, but is also present in the brain, kidney, and cardiovascular system. This distribution suggests a role in cardiovascular and renal regulation. We hypothesize that TRPM3 channels may play a role in blood pressure (BP) regulation via both vascular and renal mechanisms. Therefore, analysis of the vascular phenotype in Trpm3-KO mice can provide insights into the channel's potential contribution to hypertension development.

Methods

BP was monitored noninvasively in conscious wild-type and Trpm3-KO mice under basal condition

SUBMITTER: Rojo-Mencia J 

PROVIDER: S-EPMC12626544 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature