Pathogenicity and Genomic Characterization of <i>Pasteurella multocida</i> Serogroup F Isolate AH01 From Porcine Pneumonia in China.

ABSTRACT: Pasteurella multocida (P. multocida), a significant animal pathogen, causes swine pneumonia and atrophic rhinitis, primarily associated with serogroups A, D, and F. Although serogroups A and D are prevalent in pigs and well-established causes of these diseases, the pathogenicity and genomic characteristics of porcine serogroup F remain poorly characterized. Here, we isolated a virulent P. multocida strain-AH01, from pigs with fatal acute respiratory disease in Anhui, China. It was characterized as a capsular Type F, lipopolysaccharide (LPS) antigen Type L3 isolate of sequence type (ST) 9. To evaluate the pathogenicity of this strain, pigs were challenged intratracheally with AH01 (6 × 10⁹ CFU), inducing acute pyrexia, dyspnea, anorexia, and rapid mortality (

SUBMITTER: Li YY 

PROVIDER: S-EPMC12626689 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature