Sex-Based Differences in BMI and LDL-C Trajectories Following Type 1 Diabetes Diagnosis in Youth.

ABSTRACT:

Introduction

Cardiovascular disease (CVD) disproportionately affects females with type 1 diabetes (T1D), yet the emergence of sex-specific metabolic risk during early disease remains unclear. We evaluated whether sex differences in BMI percentile (BMIp) and LDL-cholesterol (LDL-C) trajectories appear within the first 2 years following T1D diagnosis.

Methods

We conducted a retrospective cohort study of 542 youth with new-onset T1D (mean age 10.4 ± 3.9 years; 54.1% male) and assessed sex differences in BMIp and LDL-C trajectories using linear mixed-effects models, adjusting for age, HBA1c and diabetic ketoacidosis (DKA) status at diagnosis, and baseline weight category (LDL-C model only).

Results

At diagnosis, median BMIp did not differ by sex (females: 50.9 [IQR: 19.2-

SUBMITTER: Tas E 

PROVIDER: S-EPMC12626691 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature