Profiles of blood-brain barrier and neurodegeneration markers in cerebrospinal fluid of patients with cerebral amyloid angiopathy.

ABSTRACT:

Introduction

There are few studies analyzing cerebrospinal fluid (CSF) in patients with cerebral amyloid angiopathy (CAA). Our goal was to compare blood-brain barrier and neurodegeneration markers in CSF in CAA patients with and without hemorrhagic markers.

Methods

In a retrospective study of patients with CAA (Boston criteria version 2.0) identified from the Aachen Memory Database and from in-hospital admission records, we compared CSF neurodegeneration markers and albumin ratio (a blood-brain barrier permeability marker) in patients with and without hemorrhagic markers.

Results

Among 371 patients with CAA, 113 patients had hemorrhagic markers (30.5%). Lower amyloid beta (Aβ) 42, lower Aβ40, and higher albumin ratio were independently associated with the presence of

SUBMITTER: Pinho J 

PROVIDER: S-EPMC12626739 | biostudies-literature | 2025 Oct-Dec

REPOSITORIES: biostudies-literature