The impact of glycated hemoglobin trajectories on hypertension risk: a retrospective cohort study.

ABSTRACT:

Background

Glycated hemoglobin (HbA1c) reliably reflects long-term glucose control and has been linked to hypertension development. This study investigates the relationship between baseline HbA1c levels, HbA1c trajectories, and hypertension risk.

Methods

This retrospective cohort study included 10,138 adults from health screenings at Henan Provincial People's Hospital (January 2018-January 2025). Mean age was 54.03 ± 12.97 years, with 31.44% women and mean follow-up of 43.92 months. We analyzed hypertension incidence across HbA1c groups using Kaplan-Meier curves and identified HbA1c trajectory patterns using latent class trajectory modeling (LCTM). Cox proportional hazards models evaluated associations between baseline HbA1c tertiles, HbA1c trajectories, and hypertension ris

SUBMITTER: Sun Y 

PROVIDER: S-EPMC12626783 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature