Durvalumab consolidation therapy in patients with stage III small cell lung cancer after concurrent chemoradiation: a China-based cost-effectiveness analysis.

ABSTRACT:

Background

Limited-stage small-cell lung cancer (LS-SCLC) has suboptimal long-term survival despite standard chemoradiotherapy. Durvalumab, an anti-PD-L1 antibody, demonstrated survival benefits in the ADRIATIC Phase III trial, but its cost-effectiveness in China remains uncertain. This study evaluates the economic value of durvalumab as consolidation therapy for LS-SCLC post-chemoradiotherapy.

Methods

A Markov model was constructed using data from the ADRIATIC trial (NCT03703297), simulating three health states: progression-free survival (PFS), progressive disease (PD), and death state, transition probabilities were derived from trial outcomes. A 10-year horizon, 5.0% discount rate, and willingness-to-pay (WTP) thresholds (1-3×per capita gross domestic product (GDP): $12,56

SUBMITTER: Zhang H 

PROVIDER: S-EPMC12626786 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature