Alterations of lipoprotein subfractions in GH-deficient adults.

ABSTRACT:

Introduction

Dyslipidemia is a common complication of adult growth hormone deficiency (AGHD) and considered an important contributor to increased mortality. Previous studies mainly focused on quantitative assessment of lipoproteins, but lipoprotein subfractions and their relationship with insulin-like growth factor 1 (IGF-1) have not been explored.

Purpose

To perform a comprehensive evaluation of lipoprotein subfractions and measuring apolipoprotein L1 (apoL1), sphingosine 1-phosphate (S1P) and apolipoprotein M (apoM) in AGHD.

Materials and methods

11 GH-substituted (GHS) patients, 9 GH-unsubstituted (GHU) patients and 37 controls were included in the study. Lipoprotein subfractions were separated by the Lipoprint system. ApoL1, apoM and S1P were determined by ELISA.

SUBMITTER: Ratku B 

PROVIDER: S-EPMC12626791 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature