Muscle function mediates the association between vitamin D deficiency and hip fracture risk: a retrospective study in older adults.

ABSTRACT:

Objectives

Hip fracture, a critical public health concern in aging populations, are associated with significant morbidity, mortality, and disability and have been referred to as "the last fracture of life." While vitamin D influences bone mineral density (BMD) and fragility fracture risk, its impact on muscle function and its relationship with fracture risk remains underexplored. This study aimed to investigate whether vitamin D deficiency increases hip fracture risk primarily through its effects on muscle function.

Methods

In this retrospective study, 138 patients aged ≥ 50 years with initial low-energy hip fracture treated between January 2024 and June 2024 were compared with 182 community residents aged ≥ 50 years recruited from the hospital physical examination center. C

SUBMITTER: Wang X 

PROVIDER: S-EPMC12626798 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature