Hypertriglyceridemia is a dose-dependent risk factor for type 2 diabetes mellitus: a systematic review and meta-analysis.

ABSTRACT:

Introduction

The prevalence of type 2 diabetes mellitus (T2DM) has more than doubled in the past 20 years. Most T2DM cases are preventable if risk factors are eliminated early. Hypertriglyceridemia (HTG) is also a potential but modifiable risk factor, and has a high prevalence as well. We aimed to investigate the dose-dependent effect of HTG on the development of T2DM.

Methods

We carried out a systematic search in three databases (MEDLINE, Embase, and CENTRAL) on 9 November 2023. We investigated an adult population with different triglyceride levels (exposure). The outcome of interest was the development of T2DM. Pooled hazard ratio (HR), odds ratio (OR), and mean differences (MDs) with 95% confidence intervals (CIs) were calculated using a random-effects model. Risk of bias

SUBMITTER: Havelda L 

PROVIDER: S-EPMC12626804 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature