Use of thyroid hormones in euthyroid patients with unexplained fatigue: analyses of aggregate data from European national surveys of professional endocrine society members.

ABSTRACT:

Background

Managing patients with fatigue is a clinical challenge. Because fatigue is often reported in hypothyroidism, thyroid hormone (TH) therapy may sometimes be incorrectly considered for biochemically euthyroid individuals. This study aimed to evaluate the prevalence and determinants of this practice in different European countries.

Methods

We analyzed aggregate data from the THESIS (Treatment of Hypothyroidism in Europe by Specialists: an International Survey) online survey. We analyzed responses from 5,695 members of 28 national endocrine/thyroid societies' specialists to the statement: "Thyroid hormones may be indicated in biochemically euthyroid patients with unexplained fatigue".

Results

Overall, 7.5% (426/5695) of respondents indicated that TH therapy migh

SUBMITTER: Bednarczuk T 

PROVIDER: S-EPMC12626830 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature