Device Insertion Versus Material: Drivers of Inflammation in Diabetes Device Interfaces.

ABSTRACT:

Background

Automated insulin delivery (AID) systems are limited by the short wear time of insulin infusion sets, which typically need replacement every 2 to 3 days, significantly shorter than the 14-day lifespan of continuous glucose monitoring (CGM) sensors. Infusion set failure remains a major obstacle to AID reliability and patient adherence. This study examined the roles of insertion trauma and biomaterial composition in causing acute inflammatory responses using both swine and mouse models.

Methodology

We evaluated three commercial CGM sensors (Abbott Libre 2, Dexcom G7, Medtronic Guardian 3) and two Teflon-based IIS catheters (Medtronic QuickSet and i-Port Advance). In swine, tissue was histologically analyzed one day after implantation to assess neutrophil extracellul

SUBMITTER: Cunegundes PS 

PROVIDER: S-EPMC12626850 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature