Cross-regulatory interaction between the HPI axis and appetite regulation in Atlantic salmon (<i>Salmo salar</i>) parr under chronic and acute stress.

ABSTRACT: Reduced feed intake is a common stress response in Atlantic salmon (Salmo salar), yet the interaction between the stress-related hypothalamic-pituitary-interrenal (HPI) axis and the appetite-regulating hypothalamic melanocortin system remains poorly understood. This study explored the potential cross-regulatory interaction between these two systems by assessing feed intake, gastrointestinal content, and hypothalamic mRNA expression of crf1 paralogs, a key factor in stress handling, and appetite-related genes npy, agrp1, pomc, and cart in Atlantic salmon parr exposed to 21 days of unpredictable chronic stress, followed by a novel acute stressor. Our results indicated that regulation of the HPI axis and appetite-regulatory mechanisms appeared to depe

SUBMITTER: Lai F 

PROVIDER: S-EPMC12626856 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature