Differential impact of overt and subclinical hypothyroidism on severe postpartum hemorrhage: a retrospective cohort study.

ABSTRACT:

Background

The impact of hypothyroidism, which can be divided into overt hypothyroidism and subclinical hypothyroidism, on severe postpartum hemorrhage (SPPH) remains unknown.

Methods

A total of 34,303 pregnant women from the Third Affiliated Hospital of Guangzhou Medical University between 2016 and 2020 were included in this retrospective cohort study. We employed three logistic regression models incorporating different covariates to explore the relationship between hypothyroidism and SPPH, followed by an interaction analysis to identify potential modifiers. Then, we performed a stratified analysis to examine the influence of potential modifiers on the association between hypothyroidism and SPPH. Finally, sensitivity analyses were conducted to evaluate the robustness of our

SUBMITTER: Zhuang J 

PROVIDER: S-EPMC12626868 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature