Physical fitness and body composition assessments in advanced cancer patients undergoing exenterative surgery - A pilot cohort study.

ABSTRACT:

Aim

Locally advanced pelvic malignancies, such as colorectal and anal cancers, can only be cured through multimodal cancer treatment including multi-visceral exenterative resections, which carry a high mortality and morbidity risk. Despite strong predictive abilities in other cancer cohorts, the combined prognostic value of body composition and cardiopulmonary exercise testing (CPET) for major in-hospital morbidity in patients undergoing exenterative surgery for advanced pelvic cancers has not been evaluated.

Method

A locally advanced colorectal and anal cancer cohort was derived from a prospectively maintained quaternary database. CPET was undertaken preoperatively, according to national guidelines. Skeletal muscle index (SMI) and radiation attenuation (SM-RA) were obtained

SUBMITTER: Looby M 

PROVIDER: S-EPMC12626906 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature