Synergistic benefits of melatonin and therapeutic exercise as a unified strategy for managing stroke and doxorubicin-induced cardiotoxicity.

ABSTRACT:

Introduction

Epidemiological studies highlight a significant occurrence of ischemic strokes in cancer patients, particularly in the elderly, where stroke and systemic cancer are the leading causes of death. This comprehensive study investigates the combined effect of melatonin (MT) and exercise (Ex) against stroke, and a chemotherapeutic drug doxorubicin (Dox)-induced cardiotoxicity (DIC).

Method

This study employs two models-middle cerebral artery occlusion (MCAo) and DIC-to evaluate the synergistic effects of MT + Ex. For both models, rats were assigned to the same treatment groups (n = 5 per group): control, vehicle, MT (10 mg/kg, twice daily), Ex (10 m/min for 30 min/day), and combined MT + Ex after either MCAo or DIC. The treatments were administered for 4 weeks.

SUBMITTER: Park S 

PROVIDER: S-EPMC12627009 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature