Transcriptomic analysis of skin biopsies in Prurigo nodularis patients: with and without atopic dermatitis.

ABSTRACT:

Background

Nodular dermatitis (PN) is a severely itchy chronic skin disease with symmetrically distributed nodules, often linked to an atopic background in some patients. However, the pathogenesis of PN with atopic dermatitis remains unclear.

Objective

The objective of this study is to compare the transcriptomes from skin biopsies of prurigo patients with and without atopic dermatitis, aiming to identify unique gene expression patterns and gain insights into the molecular mechanisms underlying Atopic dermatitis Prurigo (ADP) and Non-Atopic dermatitis Prurigo (NADP).

Method

We conducted transcriptome analysis to compare gene expression between normal controls and atopic dermatitis patients, identifying DEGs and performing KEGG and GO analyses, along with correlations b

SUBMITTER: Lee SY 

PROVIDER: S-EPMC12627025 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature