The roles of Bcl-xL in modulating apoptosis during development of Xenopus laevis.

ABSTRACT:

Background

Apoptosis is a common and essential aspect of development. It is particularly prevalent in the central nervous system and during remodelling processes such as formation of the digits and in amphibian metamorphosis. Apoptosis, which is dependent upon a balance between pro- and anti-apoptotic factors, also enables the embryo to rid itself of cells damaged by gamma irradiation. In this study, the roles of the anti-apoptotic factor Bcl-xL in protecting cells from apoptosis were examined in Xenopus laevis embryos using transgenesis to overexpress the XR11 gene, which encodes Bcl-xL. The effects on developmental, thyroid hormone-induced and gamma-radiation-induced apoptosis in embryos were examined in these transgenic animals.

Results

Apoptosis was abrogated in XR11 tra

SUBMITTER: Johnston J 

PROVIDER: S-EPMC1262703 | biostudies-literature | 2005 Sep

REPOSITORIES: biostudies-literature