Evidence of recombination among early-vaccination era measles virus strains.

ABSTRACT:

Background

The advent of live-attenuated vaccines against measles virus during the 1960'ies changed the circulation dynamics of the virus. Earlier the virus was indigenous to countries worldwide, but now it is mediated by a limited number of evolutionary lineages causing sporadic outbreaks/epidemics of measles or circulating in geographically restricted endemic areas of Africa, Asia and Europe. We expect that the evolutionary dynamics of measles virus has changed from a situation where a variety of genomic variants co-circulates in an epidemic with relatively high probabilities of co-infection of the individual to a situation where a co-infection with strains from evolutionary different lineages is unlikely.

Results

We performed an analysis of the partial sequences of the he

SUBMITTER: Schierup MH 

PROVIDER: S-EPMC1262704 | biostudies-literature | 2005 Oct

REPOSITORIES: biostudies-literature